Context: Kinetic models could assist clinicians potentially in managing cases of lead poisoning. Several models exist that can simulate lead kinetics but none of them can predict the effect of
Target-mediated drug disposition (TMDD) is a phenomenon characterized by a drug’s high-affinity binding to a target molecule, which significantly influences its pharmacokinetic profile within an organ
Appendix S1, Mass Action differential equations for the kinetic model for transport from the mass action reactions shown in Eqs. (1) and (2) are shown. Glossary S1, Definitions of variables and parame
The parameters a, k and v (see text) are either assumed to vary among tissues (T) or to have a common value across all four tissues (C). In Model E the parameter k is set to the value 1 for all tissue