Sulfoximine-Assisted Unsymmetrical Twofold C–H Functionalization of Arenes
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https://figshare.com/articles/dataset/Sulfoximine-Assisted_Unsymmetrical_Twofold_C_H_Functionalization_of_Arenes/12529352
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资源简介：
An
unprecedented ruthenium (Ru)-catalyzed twofold unsymmetrical
annulation of 3-O/N-allyl benzoic acid derivatives with isocyanates
for the construction of dihydro-furan/indole-fused phthalimide scaffolds
is discussed. This double-unsymmetrical functionalization of both o,o’-C–H bonds of arene moiety
is explicitly viable under the influence of methylphenyl sulfoximine
directing group constructing three different [C–C/C–C(O)/N–C(O)]
bonds under a single catalytic system. A broad scope with all six-carbon-substituted
arene motifs, control experiments, and gram-scale synthesis make the
synthetic model viable and significant.
创建时间：
2020-06-10
