Mus musculus Genome sequencing

Chromatin-state-specific dysregulation is a hallmark of ß cell dysfunction. As previously reported, accessible chromatin is contrast to the distinct allelic DNA methylomes. The dynamics of chromatin are associated with epigenomic programming of chromatin such as DNA methylation and histone modifications. Recently, the highly efficient approach assay for transposase-accessible chromatin sequencing (ATAC-seq) was developed, which can probe accessible regions. This technology provided a new and sensitive way to track open chromatin regions and allowed us to better study the effect of epigenetic changes.