The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing

The Moonwalker (Mwk) mouse is a model of dominantly inherited cerebellar ataxia caused by a gain-of-function mutation in the transient receptor potential (TRP) channel TRPC3. We report impairments in dendritic growth and synapse formation early on during Purkinje cell development in the Mwk cerebellum that are accompanied by alterations in calcium signaling.月行（Mwk）小鼠是一种由瞬时感受器电位（transient receptor potential, TRP）通道TRPC3的功能获得性突变所引发的常染色体显性遗传性小脑共济失调模型。本研究报道了Mwk小鼠小脑内浦肯野细胞（Purkinje cell）发育早期出现的树突生长与突触形成缺陷，该异常伴随钙信号转导的改变。