Chronic Stress Reinforces the BLA-mPFC-LHb Neural Circuit Leading to Depression

To explore the specific subset of mPFC neurons involved in the pathophysiological process of CRS-induced depression, we performed RNAseq between noCRS and CRS treatment mice to identify the enriched genes and possible pathway. GO:BP analysis identified significantly enriched genes that are involved in synaptic signaling and regulation of membrane potential pathways. Overall design: Differential expression analysis and GO Enrichment Analysis of RNA seq data. We performed differential expression analysis of RNA seq data obtained from mPFC-LHB projection neurons of noCRS and CRS mice.