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Codanin-1 Mutations Engineered in Human Erythroid Cells Demonstrate Role of CDAN1 in Terminal Erythroid Maturation

NIAID Data Ecosystem2026-03-12 收录

血细胞终末分化

CDAN1基因功能

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE151476 数据链接链接失效反馈

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资源简介：

CDAN1, and residue R1042, have a function in DNA replication and organization in terminal erythroid maturation. Six samples (3 controls and 3 mutants)

应用场景：

创建时间：

2021-03-31

血细胞终末分化

免疫基因组学

The terminal differentiation of B cells into antibody-secreting cells (ASCs) is a critical component of adaptive immune responses. Using our in vitro differentiation system, we combined RNA sequencing

NIAID Data Ecosystem80

Terminally maturing erythroblasts have dynamic changes in transcription-related chromatin modifications and RNA Polymerase II occupancy (RNA-Seq)

血细胞终末分化

表观遗传

We suggest a novel paradigm for understanding the epigenetic mechanisms that govern terminal erythroid maturation, and underlie inherited and acquired erythroid disease. Two replicates of CD36 synchro

NIAID Data Ecosystem20

RNA polymerase II pausing contributes to maintain chromatin organization in erythrocytes [Hi-C]. RNA polymerase II pausing contributes to maintain chromatin organization in erythrocytes [Hi-C]

染色质三维结构调控

血细胞终末分化

Chicken erythrocytes are nucleated cells often referred to as transcriptionally inactive, although the epigenetic changes and chromatin remodeling that mediate transcriptional repression and the exten

NIAID Data Ecosystem20

Terminally maturing erythroblasts have dynamic changes in transcription-related chromatin modifications and RNA Polymerase II occupancy (ChIP-Seq 1)

血细胞终末分化

表观遗传调控

NIAID Data Ecosystem40

The RNA m6A binding protein YTHDF2 promotes the B cell to plasma cell transition

血细胞终末分化

表观转录组调控

The B cell to plasma cell transition relies on the coordinated remodelling of the gene expression program. We performed a CRISPR/Cas9 knockout screen of RNA binding proteins to identify post-transcrip

NIAID Data Ecosystem20

Codanin-1 Mutations Engineered in Human Erythroid Cells Demonstrate Role of CDAN1 in Terminal Erythroid Maturation

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