Innovative model system for studying the biology of Down syndrome (DS) has been developed using DS-specific iPSCs and human X-inactivation gene, XIST. In this cell line, XIST was inserted into one cop
The anterior thalamic nuclei are important for spatial and episodic memory, however, there is surprisingly little information about how these nuclei are affected in many conditions that present with m
Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 486,000 CpGs. Dataset included 71 samples from multiple brain regions (cerebellum, temporal/occipit
Down syndrome (DS) is the most common genetic cause of cognitive disability. However, it is largely unclear how the triplication of a small gene subset may impinge on diverse aspects of DS brain physi