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ALKBH5 regulates AML development and LSC as an m6A eraser. ALKBH5 regulates AML development and LSC as an m6A eraser

NIAID Data Ecosystem2026-03-11 收录

RNA表观遗传学

急性髓系白血病

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA605566 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2020-02-08

急性髓系白血病

RNA测序

We investigated the role of the transcriptional regulators Id2 and E2-2 (encoded by Tcf4) in the context of MLL-rearranged acute myeloid leukemia (AML). Using an AML mouse model driven by a Tet-off in

干细胞与再生医学数据中心2022-02-20 更新80

Conserved and divergent functions of N6-methyladenosine RNA methyltransferase METTL4 during evolution.

RNA表观遗传学

剪接体调控

This study aims to investigate the enzymatic properties and evolutionary conservation of METTL4, a novel internal m6A(m) methyltransferase involved in U2 snRNA modification during spliceosome assembly

NIAID Data Ecosystem10

STAT3 inhibition permits epigenetic reprogramming and TLR9/IRF8-driven differentiation of inv(16) acute myeloid leukemia [RRBS]

急性髓系白血病

IRF8介导的白血病细胞分化

Cultured acute myeloid leukemia (AML) blasts can differentiate into antigen-presenting cells but achieving leukemic cell immunogenicity proved challenging in clinical setting. Despite expressing multi

NIAID Data Ecosystem10

Additional file 1 of The alteration of N6-methyladenosine (m6A) modification at the transcriptome-wide level in response of heat stress in bovine mammary epithelial cells

RNA表观遗传学

热激应激响应

Additional file 1. m6A peaks in H and NH groups.

Figshare2024-02-07 更新10

Additional file 3 of The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression

胆管癌分子机制

RNA表观遗传学

Additional file 3: Table S2. Overlapping genes identified by m6A-seq from METTL16 knockout and control CCLP1 and HuCCT1 cells.

Figshare2024-08-16 更新10