Mean baseline and 6 month values and the mean absolute changes in insulin sensitivity, insulin secretion and β-cell function in the treatment and placebo group.

Baseline and 6 month data are presented as mean (SD).
*A multivariate 2-factor repeated-measures regression analysis was used to assess time effects and time by treatment effect interactions on all outcome variables after adjustment for the variables that were different between treatment groups at baseline. Numbers in brackets represent unadjusted P values.
†Logarithmically-transformed variables.
‡Calculated by multiplying Matsuda index by AUC for C-peptide.
AUC, area under the curve; HOMA2%S, Homeostasis Model Assessment 2 index of insulin sensitivity.
Mean baseline and 6 month values and the mean absolute changes in insulin sensitivity, insulin secretion and β-cell function in the treatment and placebo group.