Deciphering the causal relationship between blood pressure and regional white matter integrity: a two-sample Mendelian randomization study

Table S1. A list of 39 regional white matter (WM) integrity measured by fractional antitropy (FA). Table S2. Self-report neurological characteristics of UK Biobank's participants from two independent association sample sets for the two-sample Mendelian randomization (MR) analysis. Table S3. Numbers of candidate instrumental variables (IVs) determined at each step of our statistical method by separately using UK Biobank (UKB) GWAS and existing meta-analyzed GWAS. Table S4. Gene annotations for determined valid instrumental variables (IVs) carried into the two-sample Mendelian Randomization (MR) analysis by separately using UK Biobank (UKB) GWAS and existing meta-analyzed GWAS. Table S5. Results of association analysis and Mendelian Randomization analysis (implemented with generalized version of inverse-variance weighted (gen-IVW) approach) in the study samples. Table S6. Results of alternative Mendelian randomization (MR) approach and sensitivity analyses by using data from UK Biobank (UKB) cohort. Table S7. Results of adaptively weighted (AW) Fisher's method and mendelian randomization analysis implemented with a generalized version of inverse-variance weights method (gen-IVW) Table S8. Results and numbers of candidate instrumental variables (IVs) in each step of our two reverse two-sample Mendelian Randomization (MR) analyses using UK Biobank (UKB) cohort. Supplmentary File. Results of leave-one-out analyses STROBE-MR checklist. STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME) checklist