Supporting data for "Multiscale Predictions of Vertebral Strength: Tissue, Microarchitecture, and Body "

Osteoporosis is a global health crisis with the fatal consequence of fragility fractures. Almost all bones in the human skeleton could occur fragility fractures, among which vertebral fractures are the most common but the hardest to define. In the past half-century, researchers in the field have put a large amount of effort to understand vertebral strength for predicting vertebral fracture risk. Generally, vertebral strength depends on three scales of mechanical characteristics. They are tissue properties (µm), trabecular microarchitecture (mm), and vertebral body (cm). Even though the previous studies have answered many significant problems, there are still some consequential questions in all three levels.Firstly, no study has asked if the mechanical properties of bone tissue could vary during deformation. Secondly, no parameter could quantify the contribution of microarchitecture to mechanical properties of cancellous bone. The third question is at the vertebral level in clinical practice. The clinical screening of patients at high vertebral fracture risk is dependent on the lumbar bone mineral density (BMD) regardless of the type of vertebral fracture. But there are various forms of BMD and three different types of vertebral fractures. Nobody has asked if the predictor of fracture risk is dependent on the type of fracture. Fourth, nonlinear finite element models that consider the fracture type are rare.The current project aims to solve the above problems. Data related to the first three problems have already been published. The current dataset mainly contains the data related to the fourth problem. It contains bone mineral measures, mechanical testing results, and finite element modelling results that relate to vertebral strength.

骨质疏松症已成为一项全球性的健康危机，其致命后果是脆性骨折。人类骨骼中的几乎所有骨骼都有发生脆性骨折的可能，其中脊椎骨折最为常见，却最难界定。在过去半个世纪中，该领域的学者们投入了大量的努力，以理解脊椎的强度，从而预测脊椎骨折的风险。通常，脊椎的强度取决于三个机械特性的尺度：组织特性（微米级别）、骨小梁微观结构（毫米级别）以及脊椎体（厘米级别）。尽管先前的研究已经解答了许多重要的问题，但在三个层面上仍存在一些具有重大意义的疑问。首先，尚未有研究探讨骨组织的机械性质在变形过程中是否会发生变异。其次，尚无参数能够量化骨小梁微观结构对松质骨机械性质的影响。第三个问题涉及临床实践中的脊椎水平。对于高脊椎骨折风险的患者的临床筛查，无论脊椎骨折的类型如何，都依赖于腰椎骨矿物质密度（BMD）。然而，存在多种形式的BMD和三种不同类型的脊椎骨折。没有人询问过骨折风险的预测是否依赖于骨折的类型。第四，考虑骨折类型的非线性有限元模型非常罕见。当前项目旨在解决上述问题。与前三问题相关的数据已经发表。当前数据集主要包含与第四个问题相关的数据。它包含与脊椎强度相关的骨矿物质测量值、机械测试结果以及有限元建模结果。