Effect of a-Ketoacid on Gut Microbiota in Rats with Chronic Kidney Disease

As nitrogen-free precursors of corresponding essential amino, a-ketoacid have been widely prescribed to end-stage renal disease patients together with a low protein diet . However, the impact of a-ketoacid on intestinal microbiota in chronic kidney disease individuals is unknown. We aimed to investigate the variation in the intestinal microbiota and metabolic profile in response to a-ketoacid treatment in an adenine-induced CKD rat model.