Data record for the article: Multiscale -omic assessment of EWSR1-NFATc2 fusion positive sarcomas identifies the mTOR pathway as a potential therapeutic target

This record provides details of the data supporting the claims of the related article: “Multiscale -omic assessment of EWSR1-NFATc2 fusion positive sarcomas identifies the mTOR pathway as a potential therapeutic target”.The related study aimed to generate genomic profiles of EWSR1 fusion positive sarcomas to support the use of precision medicine in the development of therapeutics for the Ewing family of tumors.Type of data: Genomic profiling data; Gene expression data; Drug sensitivity data; TCGA datasets, copy number data; case report data Subject of data: EWSR1 fusion positive sarcoma patientsSample size: 1,024 retrospectively analysed samples, 1 case reportData accessThe genomic profiling of pathogenic variants in EWSR1-NFATc2 fusion positive sarcomas are openly available as part of this figshare metadata record in the file ‘Variants observed in EWSR1-NFATc2 sarcoma.xlsx’. The gene expression data used in this study are openly available from the Gene Expression Omnibus repository via the following accessions: https://identifiers.org/geo:GSE60740 and https://identifiers.org/geo:GSE34620. The drug sensitivity data files used in this study were Cell_Lines_Details.xlsx; GDSC1_fitted_dose_response_17Jul19.xlsx; GDSC2_fitted_dose_response_17Jul19.xlsx; mutations_latest.csv; gene_cnv_2019-04-15_1109.csv; rnaseq_latest.csv. All of these files are openly accessible from the Genomics of Drug Sensitivity in Cancer Database (https://www.cancerrxgene.org/).The TCGA dataset files used in this study were the Clinical merged and illuminahiseq_rnaseqv2-RSEM_genes_normalized files for each of the 33 cancer types. All of these files are openly accessible from firebrowse.org (http://gdac.broadinstitute.org/runs/stddata__2016_01_28/data/).The copy number data files for each of the 33 cancer types were downloaded from cBioPortal (https://www.cbioportal.org/).The case report data cannot be openly shared in order to protect patient confidentiality De-identified information is available in the text and supplemental figures of the related article. Clinical and genomic data for this case can be made available on request. Corresponding author for this studyJames L. Chen ([e-mail])Study approval Western Institutional Review Board (protocol No. 20152817)