Reclassification of predicted risk with the addition of weighted combined genetic score (CGS) including 8 variants (P<0.05) in T2D subjects (upper panel) and healthy controls (lower panel).

CGS: combined genetic score. Each cell refers to the number of subjects in the predicted risk categories. Subjects with higher predicted risk were more likely to be classified as cases. Similarly, subjects with lower predicted risk were more likely to be classified as controls. T2D subjects and healthy controls classified in the shaded cells indicated that they were correctly reclassified to higher and lower risk categories, respectively. The total number of subjects reclassified is 3,021 and the improvement classification rates are 4.36% and 6.99% for T2D subjects and healthy controls, respectively with a total improvement rate of 11.4% (4.36% +6.99%).