Crystal structure of p53 cancer mutant Y220C in complex with rezatapopt analog 7

Crystal structure of p53 cancer mutant Y220C in complex with rezatapopt analog 7 Descriptor: 1,2-ETHANEDIOL, 2-[3-[(4-dimethylphosphorylphenyl)amino]prop-1-ynyl]-~{N}-(1-methylpiperidin-4-yl)-1-[2,2,2-tris(fluoranyl)ethyl]indol-4-amine, Cellular tumor antigen p53, ... Authors: Mavridi, D, Balourdas, D.I, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) Deposit date: 2025-08-06 Release date: 2026-03-11 Last modified: 2026-04-01 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt. Cell Death Dis, 17, 2026