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MLH1 mutation.
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创建时间：
2022-06-16
相关数据集
Anti-recombination function of MutSa restricts telomere extension by ALT-associated homology directed repair.
Alternative lengthening of telomeres (ALT) is a telomere elongation mechanism observed in ~15% of cancer subtypes. Current models indicate that ALT is mediated by homology-directed repair mechanisms.
NIAID Data Ecosystem40
Stabilization of diverged tandem repeats by mismatch repair: evidence for deletion formation via a misaligned replication intermediate.
A functional methyl-directed mismatch repair pathway in Escherichia coli prevents the formation of deletions between 101-bp tandem repeats with 4% sequence divergence. Deletions between perfectly homo
PubMed Central1996-07-09 更新30
Different mutator phenotypes in Mlh1- versus Pms2-deficient mice
Deficiencies in DNA mismatch repair (MMR) result in increased mutation rates and cancer risk in both humans and mice. Mouse strains homozygous for knockouts of either the Pms2 or Mlh1 MMR gene develop
PubMed Central1999-06-08 更新00
mouse exome. Mus musculus
Whole exome sequencing of WT and Msh2-/- MEFs at each stage was performed and analyzed. Samples were prepared from WT and Msh2-/- MEFs at each stage based on the protocol (Agilent).
NIAID Data Ecosystem40
Requirement for Phe36 for DNA binding and mismatch repair by Escherichia coli MutS protein
The MutS family of DNA repair proteins recognizes base pair mismatches and insertion/deletion mismatches and targets them for repair in a strand-specific manner. Photocrosslinking and mutational studi
PubMed Central2000-09-15 更新20
