Dynamic changes in glomerular cells in the development of diabetes

To investigate dynamic changes in glomerular cells, including podocyte, mesangial cells and glomerular endothelial cells, in the development of diabetic nephropathy We then performed gene expression profiling analysis using data obtained from RNA-seq of glomerular cells of control(m/m), diabetic (db-/- 6-week-old) and diabetic nephropathy (db-/- 10-week-old with albuminuria) mice Comparative gene expression profiling analysis of RNA-seq data for isolated glomerulare cells为探究糖尿病肾病（diabetic nephropathy）发生发展进程中，包括足细胞（podocyte）、系膜细胞（mesangial cells）及肾小球内皮细胞（glomerular endothelial cells）在内的各类肾小球细胞的动态变化，我们利用对照组（m/m基因型）、糖尿病模型组（6周龄db-/-小鼠）及糖尿病肾病模型组（10周龄伴蛋白尿的db-/-小鼠）的肾小球细胞RNA测序（RNA-seq）数据开展了基因表达谱分析，并针对分离获得的肾小球细胞的RNA测序数据完成了对比基因表达谱分析。