4 months old Scl-tta; H2B-GFP mice where chased with Doxycyclin for 18 months from and then sacrificed at 22 months of age. GFP+ and GFP- cells, or dormant and active HSCs were then sorted and sequenc
To explore the mechanism of miR-582-5p affecting NSC stemness, we transfected miR-582-5p mimics in cultured neurospheres from E14.5 embryos, and performed RNA sequencing. The results showed that 60 ge
A common and shared biology across diverse animal species is that adult tissue homeostasis is ultimately regulated by stem cell proliferation, differentiation, and self-renewal. Aberrant activation of