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Crystal structure of Dot1L in complex with adenosine and inhibitor CPD1 [N6-(2,6-dichlorophenyl)-N6-(pent-2-yn-1-yl)quinoline-4,6-diamine]

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Protein Data Bank Japan2024-01-17 更新2026-03-21 收录
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Crystal structure of Dot1L in complex with adenosine and inhibitor CPD1 [N6-(2,6-dichlorophenyl)-N6-(pent-2-yn-1-yl)quinoline-4,6-diamine] Descriptor: ADENOSINE, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... Authors: Be, C, Koch, E, Gaul, C, Stauffer, F, Moebitz, H, Scheufler, C. Deposit date: 2017-01-17 Release date: 2017-03-22 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach. ACS Med Chem Lett, 8, 2017
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2017-01-17
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