While immune checkpoint blockade (ICB) has shown promise for clinical cancer therapy, its efficacy has only been observed in a limited subset of patients and the underlying mechanisms regulating innat

NIAID Data Ecosystem30

DataSheet_2_Cyclic adenosine monophosphate/phosphodiesterase 4 pathway associated with immune infiltration and PD-L1 expression in lung adenocarcinoma cells.zip

肺腺癌免疫逃逸机制

PD-L1调控

BackgroundThe cyclic adenosine monophosphate/phosphodiesterase 4 (cAMP/PDE4) pathway is involved in inflammation and immune regulation; however, the effect of cAMP/PDE4 on immune infiltration and immu

NIAID Data Ecosystem10

SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion.

肿瘤免疫逃逸

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem30

Extended Data Fig. 3a SUPPRIME

肿瘤免疫逃逸

免疫细胞识别

C1R cells expressing different MICA alleles were incubated with PBMCs from healthy donors for 4 hours. A range of doses of MICAB1-Fc silent or isotype control mAb was added to the cells. The variation

Figshare2021-08-07 更新20

DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion

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