Clinical characteristics and carrier status.

Statistical correlation of clinical variables and carriers status. Multifocal tumours was defined as bilateral pheochromocytoma or multiple paraganglioma tumours. *Patients with no available germline DNA were excluded. **Included 14 germline variants and 4 patients with clinical criteria of Neurofibromatosis type 1. ***Nine patients had metastatic disease, one of these had metastatic disease at the time of diagnosis and the remaining had metastatic recurrences later on in the disease course. §Mann-Whitney U Test and §§Chi Square test.