Ruthenium-Catalyzed Decarboxylative C–H Alkenylation in Aqueous Media: Synthesis of Tetrahydropyridoindoles

We disclose herein a Ru­(II)-catalyzed decarboxylative and oxidative coupling of N-substituted indolyl carboxylic acids with broad substrate scope in an aqueous solution. This method provides a sustainable and efficient access to synthesize various indole-fused cyclohexanyl acetic acids under mild conditions.