MAPK4,6 translocate to the cytoplasm

Despite differences in their overall cellular distribution (MAPK6 is found in both the nucleus and the cytosol, while MAPK4 is predominantly found in the cytosol), both MAPK4 and 6 shuttle between the cytosol and the nucleus. Nuclear import of both proteins occurs through an active temperature sensitive pathway, while nuclear export depends on XPO1 (Aberg et al, 2006; Julien et al, 2003).

尽管在整体细胞分布上存在差异（MAPK6存在于细胞核和细胞质中，而MAPK4主要存在于细胞质中），但MAPK4和6均在细胞质与细胞核之间穿梭。这两种蛋白质的核输入通过一种活性温度敏感的途径实现，而核输出则依赖于XPO1（Aberg等，2006年；Julien等，2003年）。