Crystal Structure of Human IDH1 R132Q in complex with NADPH

Protein Data Bank Japan2024-05-22 更新2026-05-23 收录

癌症相关酶突变体结构解析

IDH1靶点耐药机制研究

数据链接：

https://pdbj.org/mine/summary/8vhc 数据链接链接失效反馈

官方服务：

资源简介：

Crystal Structure of Human IDH1 R132Q in complex with NADPH Descriptor: GLYCEROL, Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Mealka, M, Sohl, C.D, Huxford, T. Deposit date: 2023-12-31 Release date: 2024-04-24 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Nat Commun, 15, 2024

创建时间：

2023-12-31

Crystal Structure of Human IDH1 R132Q in complex with NADPH

资源简介：

相关数据集