hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity
收藏中国科学院中国科学技术大学科学数据中心2026-01-10 收录
下载链接：
https://sdc.ustc.edu.cn/dataDetails/SbUaOJYBQwfvTVc55-Ux
下载链接
链接失效反馈官方服务：
资源简介：
RNA metabolism involves complex and regulated processes, some of which include transcription, intracellular transport, translation, and degradation. The involvement of RNA binding proteins in these processes remains mostly uncharacterized regarding brain functions, especially cognition. In this study, we report that knockdown of hnRNPM in the CA1 hippocampal region of the mouse brain leads to learning and memory impairment. This finding is further supported, by the reduction of pre- and post-synaptic protein levels synaptophysin and PSD95. Notably, loss of hnRNPM affects the physiological spine in-vivo by impairing the morphology of the dendritic spines. Additionally, the study demonstrates that hnRNPM directly binds to the 3´UTR of synaptophysin and PSD95 mRNAs, resulting in the stabilization of these mRNAs. Together, these findings present novel insight into the regulatory role of hnRNPM in neuronal structure and function
提供机构：
中国科学技术大学
创建时间：
2023-11-08
