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Synthesis and crystal structure of two new Zn(II) and Ni(II) coordination polymers with anti-ovarian cancer activity

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DataCite Commons2024-02-14 更新2024-07-28 收录
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https://tandf.figshare.com/articles/dataset/Synthesis_and_crystal_structure_of_two_new_Zn_II_and_Ni_II_coordination_polymers_with_anti-ovarian_cancer_activity/13332813
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By using a mixed-ligand approach, two new coordination polymers with the chemical formula of {[Zn(L)(ip)·H<sub>2</sub>O]<sub>8</sub>}<sub>n</sub> (<b>1</b>, H<sub>2</sub>ip = isophthalic acid and L = 1,1’-(2-methylpropane-1,3-diyl)bis(1H-benzo[d]imidazole)) and {[Ni(L)(tdc)·2H<sub>2</sub>O]<sub>2</sub>}<sub>n</sub> (<b>2</b>, H<sub>2</sub>tdc = 2,5-thiophenedicarboxylic acid) have been hydrothermally synthesized and structurally characterized by single-crystal X-ray diffraction analyses, powder X-ray diffraction, thermogravimetric analysis and elemental analysis. In addition, <i>in vitro</i> anticancer activity of compounds <b>1</b> and <b>2</b> on four human ovarian cancer cells (CoC1, A2780, 3AO and OVCAR) was further determined. The results showed that compared with their organic ligands, the two compounds displayed efficient antitumor activity.
提供机构:
Taylor & Francis
创建时间:
2020-12-04
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