Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED-BioLINCC)

<u>**Data Access NOTE:**</u> Please refer to the &#8220;Authorized Access&#8221; section below for information about how access to the data from this accession differs from many other dbGaP accessions.

**Objectives**:** **To determine the sensitivities and specificities of ventillation/perfusion (V/Q) lung scans for acute pulmonary embolism (PE).

**Participants**:** **A total of 1487 participants were enrolled.

**Conclusions**:** **Almost all participants with pulmonary embolism had abnormal scans of high, intermediate, or low probability, but so did most without pulmonary embolism. Only in a minority of participants did the clinical assessment combined with the V/Q scan interpretation improve the overall chance of reaching a correct diagnosis of acute PE. Although a high probability scan usually indicated the presence of PE, only a small number of participants with PE had a high probability scan.

Reference: PIOPED Investigators, 1990, PMID: [2332918](https://pubmed.ncbi.nlm.nih.gov/2332918/).