Researcher Project: Interplay between Environmental Contaminants, Genes and Diet in Obesity (2/3), 2014.

This dataset consists of data from "Researcher Project: Interplay between Environmental Contaminants, Genes and Diet in Obesity, 2014". The prevalence of both obesity and colorectal cancer has increased substantially in the last decades. Simultaneously have humans been exposed to increasing amounts of environmental contaminants. This project studies fundamental questions related to the interplay between environmental contaminants, genes and health outcomes, obesity and intestinal cancer in mouse models. Mechanisms for how obesity affects intestinal tumorigenesis and how environmental contaminants may contribute to obesity were studied along two main hypotheses, via insulin resistance/hyperinsulinemia and/or inflammation. The project aims to increase the understanding of the mutual causal relationship between obesity and susceptibility for environmental contaminants, causing intestinal cancer. The results will also be useful in human risk assessment of substances such as perfluorooctanoic acid, for which data on toxic effects and dose-response relationships are still lacking.

The project includes three subprojects (publications). This dataset consists of data from the second subproject.