Average values and standard deviation (in bracket) of depth function for epitopes and non-epitopes.

aChakravarty depth is introduced by [37] and computed following [46].
b means that the average of conservation scores is significantly smaller than the average of conservation scores of non-epitopes at p-value<0.05 using Wilcoxon rank sum test with one-side test.
c DPX is the average of constituent atom DPX values, DPX is calculated following [38].
dHSEAU/HSEAD: Half-Sphere Exposure using Cα position and selected Up/Down half-sphere, HSEBU/HSEBD: Half-Sphere Exposure using Cβ position and selected Up/Down half sphere. Radius of sphere 13Å is used.
eHSD: half space depth which was firstly introduced by [41], and used in [47, 48].
Average values and standard deviation (in bracket) of depth function for epitopes and non-epitopes.