Consequences of depleting core RNAi factors on miRNA profiles
收藏NIAID Data Ecosystem2026-05-01 收录
下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP399587
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资源简介：
In this study, we used CRISPR/Cas9 to deplete HCT116 cells of DROSHA, AGO1, AGO2, AGO1/2, AGO1/2/3, TNRC6A/B, TNRC6/B + siTNRC6C, TNRC6A/B-/- + siGL2, WT, WT + siGL2, WT + siTNRC6C. Then, we used these KO and siRNA KD cell lines to measure resulting miRNA profiles. Overall design: Comparative gene expression profiling analysis of small-RNA-seq data for HCT116 cells and its KO derivatives (DROSHA-/-, AGO1-/-, AGO2-/-, AGO1/2-/-, AGO1/2/3-/-, TNRC6A/B-/-, TNRC6/B-/- + siTNRC6C, TNRC6A/B-/- + siGL2, WT, WT + siGL2, WT + siTNRC6C).
创建时间：
2023-08-09
