NOC-induced DNA adduct formation by uncured and nitrite-cured pork containing different amounts of fat (1, 5, 20%) before and after <i>in</i><i>vitro</i> digestion.

O6-carboxy-methylguanine (O6-C-MeG) was not detected (nd) in meat before digestion (BD) (total n = 12) and after duodenal (D) digestion (total n = 36). O6-C-MeG in colonic (C1, C2, C3) digests were analyzed separately (total n = 12 per fecal inoculum), due to the very high variation between fecal inocula, using a linear model with the fixed effects of fat content (F), nitrite-curing (NC) and their interaction term (F×NC). RMSE = root mean square error; a, b, c = means for different fat content (within curing treatment) with different superscripts are significantly different (P<0.05); * = significantly different from uncured equivalent (P<0.05).