whole transcriptome expression profiles of high glucose-induced memory in human umbilical vein endothelial cells

A long-term ‘memory’ of hyperglycemic stress, even when glycaemia is normalized, has been previously reported in endothelial cells. In this report, we sought to screen the genes which participate in metabolic memory in the whole transcriptome level. Methods: In the present research, whole transcriptome expression profiles were screened in normal-glucose (LG), high-glucose (HG), and metabolic memory (MM) of human umbilical vein endothelial cells (HUVECs) by RNA sequencing