Organocatalytic Asymmetric Michael–Michael Cascade for the Construction of Highly Functionalized N‑Fused Piperidinoindoline Derivatives

Application of indolin-3-one derivatives
in a cascade reaction
for efficient assembly of complex molecules is a much less explored
research area. It is demonstrated that structurally interesting polysubstituted
piperidino­[1,2-a]­indoline compounds containing four
contiguous stereocenters including one tetrasubstituted carbon center
can be readily obtained with good yields (up to 94% yield) and excellent
enantioselectivities (up to >99% ee) by employing indolin-3-one
derivatives
as substrates via bifunctional catalysis.