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MALT1-dependent cleavage of HOIL1 modulates canonical NF-kB signaling and inflammatory responsiveness

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE181493
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From patient-derived HOIL1-deficient skin fibroblasts transduced with WT and p.Arg165Lys (R/K) HOIL1, we performed differential expression analysis, gene set enrichment, and pathway analyses by RNA-Seq to demonstrate exaggerated activation of inflammatory pathways. Transcriptome profiling of untransduced and WT or p.Arg165Lys (R/K) HOIL1-transduced HOIL1-deficient patient skin fibroblasts in technical triplicate, with or without stimulation (4hrs 10ng/mL IL-1b)
创建时间:
2021-11-19
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