Additional file 5 of MicroRNA and mRNA profiling in the idiopathic inflammatory myopathies

Additional file 5 Canonical Pathways with an enrichment of significantly differentially expressed genes in idiopathic inflammatory myopathy patients PM Polymyositis, DM Dermatomyositis, IBM Inclusion body myositis, Anti-Jo1 Subset of PM and DM with anti-Jo1 autoantibodies QIAGEN’s Ingenuity Pathway Analysis (IPA) ‘Canonical Pathways’ analysis was performed on differential expression results from RNA sequencing of 7 PM and 7 DM (5 anti-Jo1 autoantibody positive), 5 IBM and 5 control whole blood samples. Columns are IPA defined canonical pathway, −log(p-value) for over-representation of dysregulated molecules in the pathway (> 1.3 is considered significant), ratio of dysregulated molecules to total molecules in pathway, activation score (z-score > 2 is significant predicted activation,