MMSET Induces Global and Focal Changes in Histone Methylation in Myeloma Cells
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https://www.ncbi.nlm.nih.gov/sra/SRP042285
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资源简介：
We investigated genome wide distribution of H3K36me2, H3K36me3 and H3K27me3 in the presence and absence of MMSET protein. MMSET overexpression in t(4;14)+ myeloma leads to global loss redistribution of H3K36me2 and genome-wide loss of H3K27 methylation. Despite the gloal decrease in H3K27me3, specific regions of the genome show enhanced H3K27me3 enrichment through increased recruitment of EZH2 methyltransferase Overall design: ChIP-seq for H3K36me2, H3K36me3 and H3K27me3 in two cell types
创建时间：
2017-09-17
