Temporal changes of gene expression in rat kidney and lung, and the effect of prior growth inhibition on these changes

Using microarrays, we investigated the changes of gene expression that occur with age in kidney and lung as growth slows down, and also investigated whether these changes were growth-driven, by asking whether prior delay of postnatal growth caused by malnutrition (tryptophan deficiency) would also delay these genetic changes.本研究借助基因芯片（microarrays），探究了肾脏与肺组织中随年龄增长且生长放缓进程出现的基因表达变化；同时，通过检测由营养不良（色氨酸缺乏）引发的产后生长延迟是否同样会延缓这类基因表达改变，以此明确上述年龄相关的基因表达变化是否由生长进程驱动。