Fluoroquinolone-resistant Cambodian Paratyphi A. Phylogenomic investigation of an outbreak of fluoroquinolone-resistant Salmonella enterica serovar Paratyphi A in Phnom Penh, Cambodia.

In early 2020, the Medical Biology Laboratory of the Institut Pasteur du Cambodge isolated an unusually high number of fluoroquinolone-resistant Salmonella enterica subspecies enterica serovar Paratyphi A strains during its routine bacteriological surveillance activities in Phnom Penh, Cambodia. A public health investigation was supported by sequencing and comparing the genomes of these Paratyphi A strains to gain insights into the genetic diversity and population structure of a potential outbreak of fluoroquinolone-resistant paratyphoid fever. Comparative genomic and phylodynamic analyses revealed the 2020 strains descended from a previously described 2013-2015 outbreak of Paratyphi A infections.