Dying cells release Damage-Associated Molecular Patterns (DAMPs) that can initiate and perpetuate sterile inflammatory responses. However, the effect of DAMPs on macrophages biology remains unclear. W
These data are the luciferase assays of nicastrin knockdown cells with and without stimulation with TNF. The firefly luciferase was NFKB-responsive, and renilla luciferase was co-transfected as a tran
Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we report here the first large-scale identification of Mediator kinase substrates in human cells (H
