Effect of Ligusticum Chuanxiong Horts Extract on Yeast gene expression under Ethanol Stress

Ethanol generated during yeast fermentation has potential oxidative damage effects, which accounts for yeast aging and death. It has been reported that water extract of Ligusticum chuanxiong Hort (Lch) exhibits anti-aging actions on Saccharomyces cerevisiae (S. cerevisiae). Here we found that ethanol stress cause carbohydrate metabolism, amino acid metabolism and ribosome biogenesis pathways were enriched. Compared with ethanol treatment, ribosome biogenesis and RNA polymerase pathways were enriched in Lch and ethanol co-treated S. cerevisiae. Additionally, glutathione metabolism pathway was exclusively enriched in S. cerevisiae with Lch and ethanol co-treatment. Taken together, these results suggest that Lch plays a protective role in S. cerevisiae to against ethanol stress by modulating ribosome biogenesis and glutathione metabolism pathways.