Study on the gut microbiota of calorie restriction mice with light-fed or dark-fed Targeted loci. Study on the gut microbiota of calorie restriction mice with light-fed or dark-fed

(Objective)To determine how the gut microbiota was modulated during the entire intervention. (Methods)We profiled gut microbiota change by gene sequencing on the V3-V4 regions of the 16S rRNA on 292 fecal samples collected at 5 time points (Day 28 after calorie restriction and Day 2, 11, 19 and 26 after ad libitum).