Certain cancers, such as ovarian clear cell carcinoma (OCCC), display high levels of genetic variation between patients, confounding the development of effective therapies. In order to identify novel
Cell-permeable peptides (CPPs) allow intracellular delivery of cargo molecules that are hooked to them. CPPs provide an efficient methodology to transfer bioactive molecules in cells, in particular in
Targeted gRNA screen against putative nucleic-acid binding proteins in a differentiation reporter strain context. By looking for gRNAs enriched in parasites no longer able to activate reporter express
We present a CRISPR-Cas9 screen in human cancer cells to identify genes that confers tumors with the ability to evade the cytotoxic effects of the immune system. We discovered that the transcriptional