Korean Colorectal Cancer Cohort RNA-seq data set from Asan Medical Center

This study presents a comprehensive molecular analysis of colorectal cancer (CRC) in Korean patients using RNA-sequencing data and clinical information. Key findings include significant differences in gene expression between tumor and normal tissues and identification of dysregulated pathways related to tumor progression. CRC samples were stratified into molecular subtypes, confirming their similarity to established CRC classifications. Immunological analysis highlighted distinguishing features between tumor and normal tissues, and some patients were found to be responsive to immunotherapy, especially those with microsatellite stable (MSS) tumors, who demonstrated a better prognosis. These insights enhance the understanding of CRC in Korean patients and support the use of RNA-seq data to inform cancer treatment and improve patient care.