Shown are the means and standard deviations for one primary (column two) and two secondary (column three and four) topology conservation metrics for the four different network randomization methods.

The average percent identity is the fraction of links the randomized network had in common with the original network. The assortativity represents the correlation between degrees of connected nodes. A positive assortativity indicates that nodes tend to be connected to nodes of similar degree, while a negative assortativity indicates that they tend to connect to nodes with different degrees. The s-metric is another link degree correlation measure; the ratios shown are the randomized network’s s-metric divided by the original network’s s-metric. All results shown were generated from 50 iterations for each method using the human FunCoup network.