CryoEM structure of a catalytically inactive CXC Chemokine-degrading protease SpyCEP from Streptococcus pyogenes complexed with an anti-PA-domain monoclonal antibody

CryoEM structure of a catalytically inactive CXC Chemokine-degrading protease SpyCEP from Streptococcus pyogenes complexed with an anti-PA-domain monoclonal antibody Descriptor: Anti-PA-domain monoclonal antibody (3F2G10) Heavy chain variable region, Anti-PA-domain monoclonal antibody (3F2G10) Light chain variable region, Cell envelope proteinase A Authors: Lau, R.J, Barritt, J.D, Wu, G.H.Y, Huemer, C.B, Matthews, S. Deposit date: 2026-06-12 Release date: 2026-07-01 Last modified: 2026-07-22 Method: ELECTRON MICROSCOPY (3.07 Å) Cite: SpyCEP dismantles neutrophil immunity via disorder-driven chemokine remodeling and GAG targeting. Proc.Natl.Acad.Sci.USA, 123, 2026