Single cell RNA-sequencing of rat gingva with diabetic periodontitis

Using single cell-RNA sequencing, we reported structural and functional changes of gingival cellulome in diabetes-associated periodontitis, with the aim to identify distinct cell populations and functions involving in disease progression. We identified inflammation-related stromal and epithelial subpopulations that expanded in diabetes-associated periodontitis, creating distinct immune microenvironment that drives the progression of the disease.本研究通过单细胞RNA测序（single-cell RNA sequencing）技术，分析了糖尿病相关性牙周炎中牙龈细胞组的结构与功能变化，旨在明确参与疾病进展的特异性细胞群及其功能。本研究鉴定出在糖尿病相关性牙周炎中扩增的炎症相关间质与上皮细胞亚群，这些亚群构建了驱动疾病进展的独特免疫微环境。