Tomm40

ENCODES a protein that exhibits monoatomic cation channel activity; preprotein binding; protein transmembrane transporter activity; INVOLVED IN positive regulation of apoptotic process; protein insertion into mitochondrial membrane; protein targeting to mitochondrion; PARTICIPATES IN beta-barrel pathway of mitochondrial protein import; carrier pathway of mitochondrial protein import; intermembrane space assembly pathway of mitochondrial protein import; ASSOCIATED WITH Experimental Diabetes Mellitus; Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN mitochondrial outer membrane; mitochondrial outer membrane translocase complex; mitochondrion; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine

编码一种展现单原子阳离子通道活性的蛋白质；参与前蛋白结合；具有蛋白跨膜转运活性；涉及凋亡过程的正调控；蛋白插入线粒体膜；蛋白靶向至线粒体；参与线粒体蛋白导入的β-桶状通路；线粒体蛋白导入的载体通路；线粒体蛋白导入的内膜空间组装通路；与实验性糖尿病（同源）、阿尔茨海默病（同源）、动物疾病模型（同源）相关；存在于线粒体外膜；线粒体外膜转运酶复合物；线粒体；与（+）-五味子素B、17β-雌二醇、2,3,7,8-四氯二苯并-对-二氧杂蒽相互作用。

搜集汇总

背景与挑战

背景概述

Tomm40数据集描述了该基因编码的蛋白质具有单原子阳离子通道活性，参与线粒体膜蛋白插入和靶向等生物过程，并与阿尔茨海默病等疾病相关。该蛋白质主要位于线粒体外膜，并与多种物质相互作用。