A systems toxicology approach reveals the Wnt-MAPK crosstalk pathway mediated reproductive failure in Caenorhabditis elegans exposed to graphene oxide (GO) but not to reduced graphene oxide (rGO).

A systems toxicology approach reveals the Wnt-MAPK crosstalk pathway mediated reproductive failure in Caenorhabditis elegans exposed to graphene oxide (GO) but not to reduced graphene oxide (rGO).本研究采用系统毒理学（systems toxicology）方法，揭示了暴露于氧化石墨烯（graphene oxide, GO）而非还原氧化石墨烯（reduced graphene oxide, rGO）的秀丽隐杆线虫（Caenorhabditis elegans）中，由Wnt-MAPK串扰通路（Wnt-MAPK crosstalk pathway）介导的生殖衰竭现象。