Bulk RNA-seq Dataset for "Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models"

This dataset supports the manuscript titled "Molecular and developmental deficits in Smith-Magenis syndrome patient hiPSC-derived cortical neural models". It includes processed single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (bulk RNA-seq) data derived from human induced pluripotent stem cell (hiPSC)-derived cortical neural progenitor cells and neurons obtained from Smith-Magenis syndrome (SMS) patients and matched healthy controls. The dataset comprises: bulkRNA-seq.zip: Normalized gene expression count tables and differential gene expression results from bulk RNA-seq analysis, along with patient-level metadata including demographic information (e.g., age, sex, diagnosis group). The data capture transcriptomic changes across developmental stages and enable the study of disease-associated molecular and cellular alterations in SMS. These files are intended for secondary analysis and reproducibility; raw FASTQ files are not included in this deposit. A companion GitHub repository with code for data preprocessing and analysis will be provided.