Enantioselective Cu-Catalyzed Arylation of Secondary Phosphine Oxides with Diaryliodonium Salts toward the Synthesis of P‑Chiral Phosphines

Catalytic synthesis of nonracemic
P-chiral phosphine derivatives
remains a significant challenge. Here we report Cu-catalyzed enantioselective
arylation of secondary phosphine oxides with diaryliodonium salts
for the synthesis of tertiary phosphine oxides with high enantiomeric
excess. The new process is demonstrated on a wide range of substrates
and leads to products that are well-established P-chiral catalysts
and ligands.